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Our interests are to use XRD, computational chemistry, NMR, and synthesis to develop new antibiotics, anti-parasitics, and anti-cancer drugs. |
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Latest 10 Publications |
433 | Malwal SR, ODowd B, Feng X, Turhanen P, Shin C, Yao J, Kim BK, Baig N, Zhou T, Bansal S, Khade RL, Zhang Y, Oldfield E.
Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways.
J Am Chem Soc. 2018 Jun 20;140(24):7568-7578. DOI: 10.1021/jacs.8b02363
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432 | Venkatramani A, Gravina Ricci C, Oldfield E, McCammon JA.
Remarkable similarity in Plasmodium falciparum and Plasmodium vivax geranylgeranyl diphosphate synthase dynamics and its implication for antimalarial drug design.
Chem Biol Drug Des. 2018 Jun;91(6):1068-1077. DOI: 10.1111/cbdd.13170
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431 | Malwal SR*, Gao J*, Hu XY*, Yang YY*, Liu WD, Huang Ko TP, Li LP, Chen CC, ODowd, B, Khade RL, Zhang Y, Zhang YH, Oldfield E, Guo, RT.
Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes.
ACS Catal., 2018, 8 (5), pp 4299–4312. DOI: 10.1021/acscatal.8b00543
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430 | Elsebaei MM*, Mohammad H*, Abouf M, Abutaleb NS, Hegazy YA, Ghiaty A, Chen L, Zhang J, Malwal SR, Oldfield E, Seleem MN, Mayhoub AS.
Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA).
Eur J Med Chem. 2018 Mar 25;148:195-209. DOI: 10.1016/j.ejmech.2018.02.031
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429 | Venkatramani A, Gravina Ricci C, Oldfield E, McCammon JA.
Remarkable similarity in Plasmodium falciparum and Plasmodium vivax geranylgeranyl diphosphate synthase dynamics and its implication for antimalarial drug design.
Chem Biol Drug Des. 2018 Jan 18. DOI: 10.1111/cbdd.13170
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428 | Gao J*, Ko TP*, Chen L*, Malwal SR*, Zhang J, Hu X, Qu F, Liu W, Huang JW, Cheng YS, Chen CC, Yang Y, Zhang Y, Oldfield E, Guo RT.
"Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase.
Angew Chem Int Ed Engl. 2018 Jan 15;57(3):683-687. DOI: 10.1002/anie.201710185
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427 | X Zhou, Y Gu, H Xiao, N Kang, Y Xie, G Zhang, Y Shi, X Hu, E Oldfield, X Zhang, Yonghui Zhang
Combining Vγ9Vδ2 T Cells with a Lipophilic Bisphosphonate Efficiently Kills Activated Hepatic Stellate Cells
Front. Immunol., 24 October 2017. doi.org/10.3389/fimmu.2017.01381.
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426 | Rao G, Bansal S, Law WX, O Dowd B, Dikanov SA, Oldfield E.
Pulsed Electron Paramagnetic Resonance Insights into the Ligand Environment of Copper in Drosophila Lysyl Oxidase.
Biochemistry. 2017 Jul 25;56(29):3770-3779. DOI: 10.1021/acs.biochem.7b00308
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425 | Boulmier A, Feng X, Oms O, Mialane P, Rivière E, Shin CJ, Yao J, Kubo T, Furuta T, Oldfield E, Dolbecq A.
Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results.
Inorg Chem. 2017 Jul 3;56(13):7558-7565. DOI: 10.1021/acs.inorgchem.7b01114
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424 | Schwalen CJ, Feng X, Liu W, O-Dowd B, Ko TP, Shin CJ, Guo RT, Mitchell DA, Oldfield E.
Head-to-Head Prenyl Synthases in Pathogenic Bacteria.
Chembiochem. 2017 Jun 1;18(11):985-991. DOI: 10.1002/cbic.201700099.
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